Cancelled
7:50 am Check-In & Coffee
8:50 am Chair’s Opening Remarks
Enhancing Safety & Durability of Cell Therapies Using Inducible & Logic-Gated Constructs
9:00 am Engineering Precision & Control in Logic-Gated CAR-T Cell Design
Synopsis
- Exploring the design and development of logic-gated CAR-T cell constructs to enhance specificity, safety, and efficacy
- Discussing the integration of multiple signaling domains and activation thresholds to achieve precise control over CAR-T cell function
- Evaluating the potential of logic-gated CAR-T cells to overcome challenges associated with on-target, off-tumor toxicity and persistence
9:30 am Prolonging Persistence & Enhancing Safety Through Inducible & Armoring Strategies
Synopsis
- Investigating the role of inducible promoters and synthetic circuits in regulating CAR-T cell activation and persistence
- Exploring various armoring strategies to protect CAR-T cells from the immunosuppressive tumor microenvironment and enhance their therapeutic efficacy
- Discussing the combination of inducible and armoring approaches to create highly potent and safe CAR-T cell therapies
10:00 am Expert Discussion – Translating Inducible & Logic-Gated Cell Therapies to the Clinic
Synopsis
- Addressing the challenges and opportunities associated with translating inducible cell therapies to clinical application
- Discussing the development of appropriate clinical trial designs and endpoints to evaluate the safety and efficacy of these advanced cell therapies
- Exploring the potential of patient-specific factors and biomarkers to optimize the selection and treatment of patients with inducible and logic-gated cells
10:30 am Morning Refreshments & Speed Networking
Addressing the Preclinical & Clinical Landscape of Complex Engineering to Treat Solid Tumours
11:00 am Advancing Engineered TIL (eTIL®) Therapies for the Treatment of Solid Tumors
Synopsis
- Exploring approaches to edit multiple T-cell targets for enhanced therapeutic efficacy against solid tumors
- Immune CRISPRomics® Platform discovered SOCS1 and Regnase-1 as top gene targets enhancing T-cell anti-tumor function
- Developing single and dual-edited eTIL® therapies with inactivation of SOCS1 and Regnase-1
11:30 am A Safer and More Efficacious Cell Therapy Construct for Solid Tumors
Synopsis
- Showcasing a head-to-head comparison “ARTEMIS vs CAR Technology” in T-cell therapy against solid tumors
- Targeting Glypican 3 (GPC3) in advanced hepatocellular carcinoma (HCC)
- Designing ARTEMIS Antibody TCR (AbTCR) T-cells to overcome major hurdles in treating solid tumors
- Infiltrating solid tumors in an immunosuppressive microenvironment
- Demonstrating superior safety and efficacy of ARTEMIS T cells
12:00 pm Panel Discussion: Translating Complex Cell Therapies into Clinical Success for Solid Tumors
Synopsis
- Sharing insights and challenges from the forefront of developing complex cell therapies for solid tumors
- Discussing strategies to enhance cell therapy efficacy and overcome the complex tumor microenvironment
- Analyzing clinical data to inform future development and optimization of complex cell therapy approaches
1 pm Lunch Break & Networking
Emerging Technologies & Applications for Complex Cell Therapy Bioengineering
2:00 pm Audience Discussion: Engineering Robust & Scalable Manufacturing Processes for Complex Cell Therapies
Synopsis
- Developing standardized, reproducible, and scalable manufacturing processes for complex bioengineered cell therapies
- Addressing the challenges of incorporating advanced cell engineering techniques into GMP-compliant manufacturing environments
- Optimizing process parameters and quality control measures to ensure product consistency and potency
2:30 pm Opportunities for Complex Bioengineering Approaches to Bring Benefits to Autoimmune Patients
Synopsis
- Developing engineered cell therapies with enhanced specificity and control to target pathogenic immune cells while preserving healthy immune function
- Designing cell therapies capable of inducing targeted immune tolerance to prevent autoimmune attacks and maintain long-term disease remission
3:00 pm What’s Next for Complex Bioengineering Approaches to Cell Therapy?
Synopsis
- Exploring novel engineering approaches for next-generation CAR constructs and current bottlenecks for current technologies
- Exploring the commercial potential of integrating CRISPR and synthetic biology to develop next-generation CAR-T products with enhanced efficacy and safety
- Investigating the future potential of multi-functional cell therapies