Cancelled
7:50 am Check-In & Coffee
8:50 am Chair’s Opening Remarks
Uniting Bioengineering Innovators to Evaluate the Cell Therapy Landscape & Latest Clinical Advancements
9:00 am Expert Panel: Navigating the Complexities of Cell Therapy Engineering & Clinical Approval
Synopsis
- A panel discussion covering a top-level overview of the latest advancements in cell therapy engineering
- Highlighting the need for “next generation” constructs and the opportunities they provide for patients
- Considering the broad challenges facing bioengineering of complex cell therapies to unveil the routes to overcoming these
9:30 am Clinical Data Presentation
Synopsis
- Session details coming soon…
10:00 am Leveraging Synthetic Biological Systems for Diverse Applications in Engineered Cell Therapies
Synopsis
- Develop sophisticated RNA-based logic circuits for precise cancer targeting, immunotherapy, organoids, and autoimmunity
- Design self-amplifying RNA therapeutics delivered in LNPs for complex cellular functions
- Utilize miRNA biomarkers to control therapeutic protein expression and RNA amplification
10:30 am Morning Refreshments & Speed Networking
Innovations in the Delivery of Novel Constructs for Advanced Cell Therapies
11:30 am Novel Technologies to Enhance Delivery Efficacy of Complex Constructs
Synopsis
- Addressing concerns with the delivery of larger and more complex constructs
- Evaluating different vectors for construct delivery
- Ensuring fitness of cells that have received these constructs to ensure survival and success
12:00 pm Harnessing Innovative Technologies to Improve Large & Complex Construct Delivery
Synopsis
- Enhancing antigen specificity, potency, and safety of transgenic cell therapies through precise genome editing
- Inducing a coordinated immune response to protect engineered T-cells from exhaustion and prolong their therapeutic effect
12:30 pm Precision Delivery of Complex Cell Therapy Cargos with DNA Origami Nanoparticles
Synopsis
- Leveraging DNA origami to construct highly precise drug delivery vehicles
- Engineering nanoparticles for targeted delivery of multiple therapeutic agents
- Exploring innovative applications of DNA origami in cell therapy and beyond
1 pm Lunch Break & Networking
Designing Cutting Edge Constructs to Enhance Cellular Functionality
2:00 pm Generating Novel CARs to Improve Cell Functionality & Enhance Therapeutic Efficacy
Synopsis
- Implementing cytokine engineering to boost cell performance
- Reprogramming cells for superior therapeutic outcomes
- Investigating CAR cells for regenerative medicine applications
2:30 pm Structural Modifications to Constructs Enabling Improved Efficacy in the Next Generation Cell Therapy
Synopsis
- Investigating the engineering strategies driving the next generation of cell therapies
- Exploring innovative approaches to modify cell therapy constructs, enhancing their potency, specificity, and persistence
- Gaining insights into the latest advancements and their potential to revolutionize clinical outcomes
3 pm Afternoon Refreshments & Networking
Utilizing Advanced Complex Engineering Approaches to Streamline Clinical Development
3:30 pm Addressing Gene Editing & Modifications to Enable More Complex Cell Therapies
Synopsis
- Leveraging CRISPR knock-in gene editing to increase sensitivity, potency, and safety of transgenic TCR-expressing T-cell therapies
- Harnessing armoring strategies to induce a coordinated immune response that resists exhaustion and allows for durable functional persistence of the engineered T-cells
4:00 pm Audience Discussion: Addressing the Complexities of Advanced Cell Therapy Engineering from an Regulatory & Operational Perspective
Synopsis
- Navigating complex interactions between engineering, clinical development, and patient needs
- Addressing infrastructure, resourcing, and financial hurdles in cell therapy commercialization
- Fostering collaboration and data-driven approaches to accelerate clinical translation and patient access